About

I graduated with MSc in Biotechnology from the Indian Institute of Technology, Mumbai, India (1993) and completed my PhD in Biotechnology, in 1999 from National Chemical Laboratory, India on a Council of Scientific and Industrial Research Fellowship. In 1999 I moved to University of Aberdeen, and did my first postdoctoral training on, transcriptional regulation of Gcn4 in Candida albicans. Between 2002 and 2005 I worked at Babraham Institute, Cambridge and University of Cambridge on IGF signalling in murine models and stem cell biology. I was appointed as RCUK academic fellow at University of Warwick in 2005 where I developed my independent research in the area of obesity and obesity related metabolic diseases such as type 2 diabetes and cardiovascular disease and held the position of Associate Professor until 2015, later moving to University of Westminster, London as Professor of Physiology. I joined University of Derby in April 2019 where I currently hold the position of Professor of Human Physiology and Head of Human Sciences Research Centre.

Research interests

My research interest is translational and multi-disciplinary with a focus towards understanding the molecular mechanisms of obesity and obesity associated metabolic diseases such as type 2 diabetes mellitus (T2D) and cardiovascular disease (CVD). My aim is to provide a better molecular understanding so that an improved therapy can be designed. For this research I mainly use Adipose Derived Stem Cells (ADSCs) and skeletal muscle cells, human samples as well as cellular and animal models to better understand the biological causes of insulin resistance. I work closely with clinicians, system biologists, bioinformaticians, imaging experts, chemists and scientists with expertise in “–omics” technologies (genomics, epigenomics, proteomics, transcriptomics and metabolomics). The two approaches used in my lab (listed below) are based on the prevention and discovery of new drug targets.

1. Obesity and Type 2 Diabetes

• Mechanisms leading to insulin resistance of adipose tissue
• Mechanisms of cell organelle dysfunction: Endoplasmic Reticulum and Mitochondria

2. Epigenetic mechanisms: Nutrient-gene interactions

• Programming of Adipose Derived Stem Cells (ADSCs)
• Maternal nutrition and fetal programming (Epigenetics)

Recent publications

2018

• L Jackisch, W Kumsaiyai, J D Moore, N Al-Daghri, I Kyrou, T M Barber, H Randeva, S Kumar, *G Tripathi, *P G McTernan (2018). Differential expression of Lp-PLA2 in obesity, type 2 diabetes and the influence of lipids. Diabetologia. 61(5), 1155-1166. (Corresponding Author) Impact Factor 206
• S P Pushpakom, A Adaikalakoteswari, A Owen, D J Back, G Tripathi, S Kumar, P McTernan, M Pirmohamed (2018) Telmisartan reverses antiretroviral-induced adipocyte toxicity and insulin resistance in vitro. Diab Vasc Dis Res. 2018 Feb 1:1479164118757924. doi: 10.1177/1479164118757924. [Epub ahead of print] Impact Factor 417
• Krishnaswamy, S., Bukhari, I., Mohammed, A.K., Amer, O.E., Tripathi, G., Alokail, M.S. and Al-Daghri, N.M. (2018) Identification of the splice variants of Recepteur d'Origine nantais (RON) in lung cancer cell lines. Gene. 679, pp. 335-340. Impact Factor 2.319.
• Abhilasha Patel, Gyanendra Tripathi, Philip McTernan, Kishore Gopalakrishnan, Omar Ali, Emma Spector, Nigel Williams, Ramesh P Arasaradnam (2018) Fibroblast growth factor 7 signalling is disrupted in colorectal cancer and is a potential marker of field cancerisation. J Gastrointestinal Oncology. Manuscript accepted. doi: 10.21037/jgo.2018.09.16

2017

• Lucia Martinez de la Escalera, Ioannis Kyrou, Jana Vrbikova, Voitech Hainer, Petra Sramkova, Martin Fried, Milan K. Piya, Sudhesh Kumar, Gyanendra Tripathi* and Philip G. McTernan. (2017) Impact of gut hormone FGF-19 on type-2 diabetes and mitochondrial recovery in a prospective study of obese diabetic women undergoing bariatric surgery. BMC Medicine. 16;15(1):34. (Corresponding author) Impact Factor 088
• Al-Daghri NM, Mohammed AK, Al-Attas OS, Ansari MGA, Wani K, Hussain SD, Sabico S, Tripathi G, Alokail MS. Vitamin D Receptor Gene Polymorphisms Modify Cardiometabolic Response to Vitamin D Supplementation in T2DM Patients. Science Report. 2017 Aug 15;7(1):8280. Impact Factor 259
• Krishnaswamy S, Mohammed AK,Tripathi G, Alokail MS, Al-Daghri NM. (2017) Splice variants of the extracellular region of RON receptor tyrosine kinase in lung cancer cell lines identified by PCR and sequencing. BMC Cancer. 2017; 17(1);738. Impact Factor 645

2016

• Perry D, Paulose Nadappuram B, Momotenko D, Voyias PD, Page A, Tripathi G, Frenguelli BG, Unwin PR. (2016) Surface Charge Visualization at Viable Living Cells. J Am Chem Soc. 138(9):3152-60. Impact Factor 357
• Hu J, Kyrou I, Tan BK, Dimitriadis GK, Ramanjaneya M, Tripathi G, Patel V, James S, Kawan M, Chen J, Randeva HS. (2016) Short-chain Fatty Acid Acetate Stimulates Adipogenesis and Mitochondrial Biogenesis via GPR43 in Brown Adipocytes. Endocrinology 2016 157(5):1881-94. Impact Factor 644
• Al-Daghri NM, Rahman S, Sabico S, Yakout S, Wani K, Al-Attas OS, Saravanan P, Tripathi G, McTernan PG, Alokail MS. (2016) Association of Vitamin B12 with Pro-Inflammatory Cytokines and Biochemical Markers Related to Cardiometabolic Risk in Saudi Subjects. Nutrients. 2016 Sep 6;8(9). Impact Factor 27
• Krishnaswamy S, Mohammed AK, Amer OE, Tripathi G, Alokail MS, Al-Daghri NM. (2016) Novel splicing variants of recepteur d'origine nantais (RON) tyrosine kinase involving exons 15-19 in lung cancer. Lung Cancer. 92:41-6. Impact Factor 958

2015

• Adaikalakoteswari A, Finer S, Voyias PD, McCarthy CM, Vatish M, Moore J, Smart-Halajko MC, Bawazeer N, Al-Daghri NM, McTernan PG, Kumar S, Hitman GA, Saravanan P and Tripathi G* (2015) Vitamin B12 in sufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes. Clinical Epigenetics. 7(1):14. (Corresponding Author) Impact Factor 091
• Reddy NL, Peng CJ, Carreira MC, Halder L, Hattersley J, Piya MK, Tripathi G, Randeva HS, Casanueva FF, McTernan PG, Kumar S, Barber TM. (2015) Enhanced thermic effect of food, postprandial NEFA suppression and raised adiponectin in obese women who eat slowly. Clin Endocrinol (Oxf). 82(6): 831-83. Impact Factor 457
• Piya MK, Harte AL, Sivakumar K, Tripathi G, Voyias PD, James S, Sabico S, Al-Daghri NM, Saravanan P, Barber TM, Kumar S, Vatish M, McTernan PG. (2014) The Identification of Irisin in Human Cerebrospinal Fluid: Influence of Adiposity, Metabolic Markers and Gestational Diabetes. Am J Physiol Endocrinol Metab. 306(5):E512-8. doi: 10.1152/ajpendo.00308.2013. Impact Factor 747
• Adaikalakoteswari A, Jayashri R, Sukumar N, Venkataraman H, Pradeepa R, Gokulakrishnan K, Anjana R, McTernan PG, Tripathi G, Patel V, Kumar S, Mohan V, Saravanan P. (2014) Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes. Cardiovasc Diabetol. 2014 Sep 26;13(1):129. Impact Factor 209
• Al-Disi DA, Al-Daghri NM, Khan N, Alfadda AA, Sallam RM, Alsaif M, Sabico S, Tripathi G, McTernan PG. (2015) Postprandial effect of a high-fat meal on endotoxemia in arab women with and without insulin-resistance-related diseases. Nutrients. 2015 Aug 4;7(8):6375-89. Impact Factor 27
• Krishnaswamy S, Mohammed AK, Amer OE, Tripathi G, Alokail MS, Al-Daghri NM. (2015) Recepteur d'Origine nantais (RON) tyrosine kinase splicing variants lacking exons 18 and 19 occur ubiquitously in lung cancer. Int J Clin Exp Med. 2015 Nov 15;8(11):20778-86. Impact Factor 227
• Al-Daghri NM, Alokail MS, Rahman S, Amer OE, Al-Attas OS, Alfawaz H, Tripathi G, Sabico S, Chrousos GP, McTernan PG, Milan PK. (2015) Habitual Physical Activity is Associated with Circulating Irisin in Healthy Controls but not in Subjects with Diabetes Mellitus Type 2. Eur J Clin Invest. 45 (8), pp. 775-781. Impact Factor 734
• Adaikalakoteswari A, Vatish M, Lawson A, Wood C, Sivakumar K, McTernan PG, Webster C, Anderson N, Yajnik CS, Tripathi G*, Saravanan P (2015) Low Maternal Vitamin B12 Status Is Associated with Lower Cord Blood HDL Cholesterol in White Caucasians Living in the UK. Nutrients. 7(4):2401-14. Impact Factor 550
• Patel A, Tripathi G, Gopalakrishnan K, Williams N, Arasaradnam RP. (2015) Field cancerisation in colorectal cancer: A new frontier or pastures past? World J Gastroenterol. 21(13):3763-72. Impact Factor 471

2014

• Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, Yousef M, Vinodson B, Amer OE, Alnaami AM, Sabico S, Tripathi G, Piya MK, McTernan PG, Chrousos GP. (2014) Maternal inheritance of circulating irisin in humans. Clin Sci (Lond). 126(12):837-44. Impact Factor 629
• Reddy NL, Jones TA, Wayte SC, Adesanya O, Sankar S, Yeo YC, Tripathi G, McTernan PG, Randeva HS, Kumar S, Hutchinson CE, Barber TM. (2014) Identification of Brown Adipose Tissue Using MR Imaging in human adult with histological and immunohistochemical confirmation. J Clin Endocrinol Metab. 99(1):E117-21. doi: 10.1210/jc.2013-2036. Impact Factor 310

2013

• Harte AL, Tripathi G, Piya MK, Barber TM, Clapham JC, Al-Daghri N, Al-Disi D, Kumsaiyai W, Saravanan P, Fowler AE, O'Hare JP, Kumar S, McTernan PG (2013) NFκB as a potent regulator of inflammation in human adipose tissue,influenced by depot, adiposity, T2DM Status and TNFα. Obesity (Silver Spring). 21(11):2322-30. (Joint 1st Author) Impact Factor 89
• SAS Aftab, N Reddy, NL Owen, R Pollitt, A Harte, PG McTernan, G Tripathi, TM Barber. (2013) Identification of a novel heterozygous mutation in exon 50 of the COL1A1 gene causing osteogenesis imperfecta. Endocrinology, Diabetes & Metabolism Case Reports, 7 2013, EDM130002, DOI: 10.1530/EDM-13-0002. Impact Factor 718

2012

• Harte AL, Varma MC, Tripathi G, McGee KM, Al-Daghri NM, Al-Attas OS, Sabico S, O'Hare JP, Ceriello A, Saravanan P, Kumar S, McTernan PG (2012) High Fat Intake leads to Acute Post-Prandial Exposure to Circulating Endotoxin in Type 2 diabetes mellitus Subjects. Diabetes Care. 35(2):375-82. Impact Factor 857
• Metcalfe D, Harte AL, Aletrari MO, Al Daghri NM, Al Disi D, Tripathi G, McTernan PG. (2012) Does endotoxaemia contribute to osteoarthritis in obese patients? Clin Sci (Lond). 123(11):627-34. Impact Factor 629
• Schisano B, Harte AL, Lois K, Saravanan P, Al-Daghri N, Al-Attas O, Knudsen LB, McTernan PG, Ceriello A, ^*Tripathi G. (2012) GLP-1 analogue, Liraglutide protects human umbilical vein endothelial cells against high glucose induced endoplasmic reticulum stress. Regul Pept. 174(1-3):46-52. Impact Factor 61
• Harte AL, da Silva NF, Miller MA, Cappuccio FP, Kelly A, O'Hare JP, Barnett AH, Al-Daghri NM, Al-Attas O, Alokail M, Sabico S, Tripathi G, Bellary S, Kumar S, McTernan PG. (2012) Telomere length attrition, a marker of biological senescence, is inversely correlated with triglycerides and cholesterol in South asian males with type 2 diabetes mellitus. Exp Diabetes Res. 2012:895185. Impact Factor 54
• McGee KC, Shahmanesh M, Boothby M, Nightingale P, Gathercole LL, Tripathi G, Harte AL, Shojaee-Moradie F, Umpleby AM, Das S, Al-Daghri NM, McTernan PG, Tomlinson JW. (2012) Evidence for a shift to anaerobic metabolism in adipose tissue in efavirenz-containing regimens for HIV with different nucleoside backbones. Antivir Ther. 17(3):495-507. Impact Factor 434

2011

• McGee KC, Harte AL, da Silva NF, Al-Daghri N, Creely SJ, Kusminski CM, Tripathi G, Levick PL, Khanolkar M, Evans M, Chittari MV, Patel V, Kumar S, McTernan PG.(2011) Visfatin is regulated by rosiglitazone in type 2 diabetes mellitus and influenced by NFκB and JNK in human abdominal subcutaneous adipocytes. PLoS One. 6(6):e20287. Impact Factor 53
• Schisano, G. Tripathi, K. McGee, P. G. McTernan and A. Ceriello (2011) Glucose oscillations, more than constant high glucose, induce p53 activation and a metabolic memory in human endothelial cells. Diabetologia; 54(5):1219-26. (Joint First Author) Impact Factor 6.88
• M. Youssef-Elabd, K. C. McGee, G. Tripathi, M. S. Abdalla, H. M. Sharada, E. A. Ashraf, I. Amin, A. Ceriello, J. P. O'Hare, S. Kumar, P. G. McTernan and A. L. Harte (2011) Acute and chronic saturated fatty acid treatment as a key instigator of the TLR-mediated inflammatory response in human adipose tissue, in vitro. J Nutr Biochem. 23(1):39-50. Impact Factor 4.59

2010

• Alhusaini, K. McGee, B. Schisano, A. Harte, P. McTernan, S. Kumar and G. Tripathi* (2010) Lipopolysaccharide, High Glucose and Saturated Fatty Acids induce endoplasmic reticulum stress in cultured primary human adipocytes: Salicylate alleviates this stress. Biochem Biophys Res Comm. 397(3):472-478. Impact Factor 2.40
• Ramanjaneya, J. Chen, J. Brown, G. Tripathi, M. Hallschmid, S. Patel , W. Kern, E. W. Hillhouse, H. Lehnert, B. K. Tan and H. S. Randeva (2010) Identification of nesfatin-1 in human and murine adipose tissue: A novel depot-specific adipokine with increased levels in obesity. Endocrinol. 151(7):3169-80. doi: 10.1210/en.2009-1358. Epub 2010 Apr 28. Impact Factor 4.644
• Al-Attas, N. Al-Daghri, A. Alfadda, D. Pritlove, A. Harte, G. Tripathi, P. McTernan and S. Kumar (2010) Adiposity and Insulin Resistance Correlate with TelomereLength in Middle-aged Arabs: The Influence of Circulating Adiponectin. Eur J. Endocrinol. 163(4):601-7. Impact Factor 4.001
• Harte AL, da Silva NF, Creely SJ, McGee KC, Billyard T, Youssef-Elabd EM, Tripathi G, Ashour E, Abdalla MS, Sharada HM, Amin AI, Burt AD, Kumar S, Day CP, McTernan PG.(2010) Elevated endotoxin levels in non-alcoholic fatty liver disease. J Inflamm. (Lond). 7(1):15- Impact Factor 22

2009

• Tripathi, D. A. M. Salih, A. C. Drozd, R. A. Cosgrove, L. C. Cobb and J. M. Pell (2009) IGF-independent effects of insulin-like growth factor binding protein-5 (Igfbp5) in vivo. FASEB J. 2009 Aug;23(8):2616-26. Impact Factor 5.48
• A. Lovett, I. Gonzalez, D. A. M. Salih, L. J. Cobb, G. Tripathi, R. A. Cosgrove, A. Murrell, P. J. Kilshaw and J. M. Pell (2006) Convergence of Igf2 expression and adhesion signalling via RhoA and p38 MAPK enhances myogenic differentiation. J. Cell Sci. 119: 4828-    Impact Factor 5.432

2005

• Tournu, G. Tripathi, G. Bertram, S. Macaskill, A. Mavor, L. Walker, F. C. Odds, N. A. R. Gow, and A. J. P. Brown (2005) Global Role of the Protein Kinase Gcn2 in the Human Pathogen Candida albicans. Eukaryotic Cell. 4: 1687-1696 Impact Factor 3.586
• M. Pell, D. A. M. Salih, L. J. Cobb, G. Tripathi, A. Drozd (2005) The Role of Insulin-Like Growth Factor Binding Proteins in Development. Rev. Endocrinol. Metab. Disord. 6(3):189-98. Impact Factor 3.807
• A. Salih, Y. Kasukawa, G. Tripathi, F. A. Lovett, N. F. Anderson, E. J. Carter, J. E. Wergedal, S. Mohan and J. M. Pell. (2005) Insulin-like growth factor binding protein-5 (Igfbp-5) has a significant effect on skeletal development that is gender- and age- related in mice. Endocrinol. 146(2):931-40. Impact Factor 4.644

2004

• A. Salih, G. Tripathi, C. Holding, M. I. González, Tadge A. M. Szestak, E. J. Carter, L. J. Cobb, Joan E. Eisemann and J. M Pell. (2004) Overexpression of Igfbp5 in mice demonstrates its significant role in growth and development. Proc. Natl. Acad. Sci. USA. 101:4314-4319. Impact Factor 10.58
• González, Tripathi, E. J. Carter, L. J. Cobb, D. A. Salih, F. Lovett, C. Holding, and J. M Pell. (2004) Akt2: a novel functional link between p38 mitogen-activated protein kinase and phospatidylinositol 3-kinase pathways in myogenesis. Mol. Cell Biol. 24:3607-22. Impact Factor 5.372
• J. Cobb, D. A. Salih, I. González, G. Tripathi, E. J. Carter, F. Lovett, C. Holding, and J. M. Pell. (2004) Partitioning of IGFBP-5 actions in myogenesis: IGF-independent anti-apoptotic function. J. Cell Sci. 117:1737-46 . Impact Factor 5.432
• Tripathi, L. H. Mahishi, T. V. N. Ramachander, S. K. Rawal. “Process for the production of polyhydroxyoctanoate by Streptomyces lividans” US Patent No. 6,692,945. Patent awarded 17th February 2004
• H. Mahishi, G. Tripathi, T. V. N. Ramachander, S. K. Rawal. “Novel E. coli having accession no. PTA 1579 and its use to produce PHB”. US Patent No. 6,756,222. Patent awarded 29th June 2004

2003

• Yin, D. Stead, L Selwy, J. Walker, G. Tripathi, T. McInerney, P. Cash, A. J. P. Brown. (2003) Proteomic analysis of the Gcn4-mediated response in Saccharomyces cerevisiae and Candida albicans. Yeast 20: S335 Suppl. 1. Impact Factor 1.955 2
• Mahishi L. H., Tripathi G. and Rawal S. K. (2003) Poly(3-hydroxybutyrate) (PHB) synthesis by recombinant Escherichia coli harbouring Streptomyces aureofaciens PHB biosynthesis genes: Effect of various carbon and nitrogen sources. Microbiol. Res. 158:9-27. Impact Factor 561

2002-1998

• Tripathi, C. Wiltshire, S. Macaskill, H. Tournu, S Budge and A. J. P. Brown. (2002) Gcn4 coordinates morphogenetic and metabolic responses to amino acid starvation in Candida albicans. EMBO J. 21:5448-5456. Impact Factor 10.75
• Tripathi, L. H. Mahishi, T. V. N. Ramachander, S. H. Phadnis, O. G. B. Nambiyar, S. K. Rawal. (2002) Construction of a Streptomyces sp.-Escherichia coli conjugative shuttle vector and its application for recombinant biosynthesis of poly(3-hydroxyalkanoic acid). Biotechnol. Lett. 24:213-218. Impact Factor 1.591
• Tripathi and S. K Rawal. (1998) Simple and efficient protocol for isolation of high molecular weight DNA from Streptomyces aureofaciens. Biotechnol. Tech. 12:629-631. Impact Factor 1.70

US Patents:

• Tripathi, L. H. Mahishi, T. V. N. Ramachander, S. K. Rawal. “Process for the production of polyhydroxyoctanoate by Streptomyces lividans” US Patent No. 6,692,945. Patent awarded 17^th February 2004
• H. Mahishi, G. Tripathi, T. V. N. Ramachander, S. K. Rawal. “Novel E. coli having accession no. PTA 1579 and its use to produce PHB”. US Patent No. 6,756,222. Patent awarded 29^th June 2004

Qualifications

• Fellow of The Higher Education Academy (FHEA)
• PhD Biotechnology
• MSc Biotechnology
• BSc Chemistry

Recent conferences

• A. Murphy, S. Azharian, G. Tripathi, G. Barker, M. Chappell and P. McTernan. (2018) A systems approach to er stress pathway dynamics reveals the impact of freeze-dried broccoli extract to mitigate inflammation in human adipocytes through the mevalonate pathway. Diabetes 67(sppl 1) 2076-p
• S. Azharian, A. Murphy, P. McTernan, M.K. Piya and G. Tripathi (2018) The effect of bariatric surgery on FGF19 and FGF12 levels on obese diabetic women. Diabetes 67(sppl 1) 1573-p
• L. Jackisch, A. Murphy, N. Al-Daghri, P. McTernan, H. Randeva, G. Tripathi*. Tunicamycin-induced er stress mediates mitochondrial dysfunction in human adipocytes. British Endocrine Society, Brighton 2016
• L. Jackisch, L. Martinez de la Escalera, A. Murphy, P. McTernan, H. Randeva, G. Tripathi*. er stress mediates mitochondrial dysfunction in human adipocytes which is exacerbated in obesity. Journal of World Mitochondria Society, 2016
• A. Adaikalakoteswari, M. Vatish, P. McTernan, P. Saravanan, G. Tripathi*. Vitamin B12 deficiency impairs insulin signalling in human adipocytes by down regulating akt via pten/trb3. Diabetic Medicine, 2016
• A. Murphy, L. Jackisch, S. Azharian, A. Aladel, G. Barker, G. Tripathi, M. Chappell, P. McTernan. Freeze-dried broccoli extract relieves er stress and mitochondrial inefficiency in differentiated human pre-adipocyte cells. British Endocrine Society, Brighton 2016
• A. Murphy, G. Tripathi, G. Barker, M. Chappell, P. McTernan. Superfood freeze-dried broccoli extract to the rescue of mitochondrial inefficiency in human mature adipocytes. Journal of World Mitochondria Society, 2016
• L. Martinez de la Escalera, L. Jackisch, A. Murphy, M. K. Piya, S. Kumar, G. Tripathi, P. McTernan. Contribution of gut-derived bacterial lps to mitochondrial dysfunction, oxidative stress and inflammation in human adipocytes. Journal of World Mitochondria Society, 2016