About

I have extensive experience in investigating the role of metabolomics in the pathogenesis of metabolic/vascular diseases and identifying health markers using mass spectrometry. Predominately looking at protein glycation and detoxification by the glyoxalase system via protein damage makers and amino acids. I was part of a large-scale (£10 million) integrating research project funded by the European Commission through its Seventh Framework Programme. The BIOCLAIMS (BIOCLAMS, Grant agreement no. 244995) project attempts to identify new "biomarkers" of the effects of food and food components on health, based on new biological technologies, in particular those of nutrigenomics and metabolomics that would contribute scientific bases for the reshaping of the European Legislation on "Health claims made on food". I have vast experience in using mass spectrometry in transitional medicine and have experience in drug therapeutic and flux metabolomics.

Teaching responsibilities

I teach across many modules across the Biomedical Science, Human Biology and Forensic Science programmes. I am a module leader of many modules and FHEA certified.

Research interests

Current research: Identifying health markers for different disease states, nutrigenomics, metabolomics and sport science, using mass spectrometry. Predominately looking at protein damage and small molecules in mechanisms of cellular senescence.

Main area of interest:

• Identifying health markers for different disease states, metabolomics and proteomics, using mass spectrometry. Investigating protein glycation and detoxification by the glyoxalase system via protein damage makers and amino acids
• Synthesis of novel biomarkers for targeted metabolomics
•  Identifying biomarkers in Chronic Obstructive Pulmonary Disease (COPD) in mechanisms of cellular senescence

Membership of professional bodies

• Associate Member of the Royal Society of Chemistry (AMRSC) (since 2016)
• Executive member of the Midlands Mass Spectrometry Group
• Member of the Covid 19 Mass Spectrometry coalition
• PGCertHE
• Patent: 2017/2018 Urinary Health Screening COAP reference (2016016)

Qualifications

• University of Warwick, UK, CV2 2D, (Research Fellow)
• University College London, UK, WC1H 0AJ, (PhD Biochemistry)
• Loughborough University, Leicester, UK, LE11 3TU (MSc Pharmaceutical Science and Medicinal Chemistry)
• Sheffield Hallam University, Sheffield, UK S1 1WB (BSc(Hons) Pharmaceutical Chemistry)

Recent publications

• Masania J, Wijten P, Keipert S, Ost M, Klaus S, Rabbani N, Thornalley PJ. 2023, Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle, Redox Biology, 59, 102574. (impact 10.21)
• Manreet Kaur, Vanessa Yardley, Ke Wang, Jinit Masania, Randolph R. J. Arroo, David B. Turner, and Mingzhong Li. 2021, Artemisinin Cocrystals for Bioavailability Enhancement. Part 2: In Vivo Bioavailability and Physiologically Based Pharmacokinetic Modeling, Molecular Pharmaceutics, 18, (12), 4272-4289. (impact 5.19)
• Manreet Kaur, Vanessa Yardley, Ke Wang, Jinit Masania, Adolfo Botana, Randolph R. J. Arroo, and Mingzhong Li. 2021, Artemisinin Cocrystals for Bioavailability Enhancement. Part 1: Formulation Design and Role of the Polymeric Excipient,Molecular Pharmaceutics,18, (12), 4256-4271. (impact 5,19)
• A. Soroh, L. Owen, N. Rahim, J. Masania, A. Abioye, O. Qutachi, L. Goodyer, J. Shen, K. Laird. 2021, Microemulsification of essential oils for the development of antimicrobial and mosquito repellent functional coatings for textiles, Journal of Applied Microbiology, 131, (6), 2808–2820. (impact: 4.059)
• Jaddoa E, Masania J, Masiero E, Sgamma T, Arroo R, Sillence D, Zetterstrom T. 2020, Effect of antidepressant drugs on the brain sphingolipid system. Journal of Psychopharmacology. 34(7):716-725. (impact 5.415)
• Jinit Masania, Gernot Faustmann, Attia Anwar, Hildegard Hafner-Giessauf, Nasir Rajpoot, Johanna Grabher, KashifRajpoot, Beate Tiran, Barbara Obermayer-Pietsch, Brigitte M. Winklhofer-Roob, JohannesM.Roob, and Naila Rabban and Paul J. Thornalley. 2019, Urinary metabolomic markers of protein glycation, oxidation and nitration in early-stage decline in metabolic, vascular and renal health, Oxidative Medicine and Cellular Longevity, 2019, 15. (impact: 7.31)
• Jinit Masania, Martin Grootveld, and Philippe Wilson. 2018, Teaching Analytical Chemistry to Pharmacy Students: A Combined, Iterative Approach, J. Chem. Educ, 95 (1), 47–54. (impact: 1.758)
• Benita C. Percival, Martin Grootveld, Miles Gibson, Yasan Osman, Marco Molinari, Fereshteh Jafari, Tarsem Sahota, Mark Martin, Federico Casanova, Melissa L. Mather, Mark Edgar, Jinit Masania and Philippe B. Wilson. 2019, Low-Field, Benchtop NMR Spectroscopy as a Potential Tool for Point-of-Care Diagnostics of Metabolic Conditions: Validation, Protocols and Computational Models, High-Throughput , 8, 2
• Benita Claire Percival, Angela Wann, Jinit Masania, Jessica Sinclair, Nikol Sullo and Martin Grootveld. 2018, Detection and Determination of Methanol and Further Potential Toxins in Human Saliva Collected from Cigarette Smokers: A 1H NMR Investigation, JSM Biotechnol Bioeng, 5 (1), 1081. (impact factor: 3.952)
• Razny , Goralska, Zdzienicka , Fedak , Masania , Rabbani, Thornalley, Pawlica-Gosiewska , Gawlik , Dembinska-Kiec , Solnica , Malczewska-Malec. 2017, Relation of the protein glycation, oxidation and nitration to the osteocalcin level in obese subjects, Acta Biochim Pol, 64 (3), 415-422. (impact factor: 1.239)
• Zhang F, Masania J, Anwar A, Zehnder D, Rabbani N, Thornalley PJ. 2016, The uremic toxin oxythiamine causes functional thiamine deficiency in end-stage renal disease by inhibiting transketolase activity, Kidney international, 90 (2 : 396-403. (Impact factor: 8.563)
• Masania J, Malczewska-Malec M, Razny U, Goralska J, Zdzienicka A, Kiec-Wilk B, Gruca A, Stancel-Mozwillo J, Demobesity. Masania J, Malczewska-Malec M, Razny U, Goralska J, Zdzienicka A, Kiec-Wilk B, Gruca A, Stancel-Mozwillo J, Dembinska-Kiec A, Rabbani N, Thornalley P. 2016, Dicarbonyl stress in clinical obesity, J Glycoconj, 33 (4), 581-9. (Impact factor: 2.52)
• Duivenvoorde LP, van Schothorst EM, Derous D, van der Stelt I, Masania J, Rabbani N, Thornalley PJ, Keijer J. 2015, Oxygen restriction as challenge test reveals early high-fat-diet-induced changes in glucose and lipid metabolism. Pflugers Arch, 467 (6), 1179-93. (Impact factor: 4.1)
• Rabbani N, Shaheen F, Anwar A, Masania J, Thornalley PJ. 2014, Assay of methylglyoxal-derived protein and nucleotide AGEs, Biochem Soc Trans, 42 (2), 511-7. (Impact factor: 4.654)
• Fleming TH, Theilen TM, Masania J, Wunderle M, Karimi J, Vittas S, Bernauer R, Bierhaus A, Rabbani N, Thornalley PJ, Kroll J, Tyedmers J, Nawrotzki R, Herzig S, Brownlee M, Nawroth PP. 2013 Aging-dependent reduction in glyoxalase 1 delays wound healing, Gerontology, 59 (5), 427-37. (Impact factor: 3.059)
• Masania J, Li J, Smerdon SJ, Macmillan D. 2010, Access to phosphoproteins and glycoproteins through semi-synthesis, Native Chemical Ligation and N-S acyl transfer, Org Biomol Chem, 8 (22), 5113-9. (Impact factor: 3.562)