About

I am a senior researcher specialising in biological and clinical mass spectrometry, including the associated data analysis pipelines.

I earned my Ph.D. in Pharmacy from the University of Nottingham and pursued my postdoctoral studies at the University of Warwick and the National University of Singapore. Prior to joining the University of Derby, I served as a research assistant professor at the Southern University of Science and Technology and as a senior consultant at the Shenzhen Academy of Metrology and Quality Inspection.

In the summer of 2024, I joined the University of Derby as the director of the Omics Lab, a core research facility specialising in metabolomics and genomics techniques. The laboratory aims to provide collaboration, consultation, and scientific services, facilitating knowledge transfer to academic, clinical, and industrial partners. I am responsible for managing and promoting the research activities of the facility, working closely with my academic and technical colleagues.

Research interests

My multidisciplinary research varied from technological and methodological development to clinical metabolomics and marine microbiology. 

Recent publications

• Feng Zhang, Fang Liu, Xiaoyi Xu, Weilan Su, Yu Rong, Fu-Ying Tian, Weimin Xiao, Yichun Wu, Kai P. Law*, and Ping Wen*, Metabolomic Profiling of Serum and Tongue Coating of Pregnant Women with Intrahepatic Cholestasis in Pregnancy. Clinica Chimica Acta 557 (2024) 117854.
• Kai P. Law*, Wei He, Jianchang Tao, and Chuanlun Zhang. A novel approach to characterize the lipidome of marine archaeon Nitrosopumilus maritimus by ion mobility mass spectrometry. Frontiers in Microbiology 12:735878 (2021). DOI: 10.3389/fmicb.2021.735878
• Kai P. Law*, Wei He, Jianchang Tao, and Chuanlun Zhang. Characterization of the exometabolome of Nitrosopumilus maritimus SCM1 by liquid chromatography–ion mobility mass spectrometry. Frontiers in Microbiology 12: 658781 (2021). DOI: 10.3389/fmicb.2021.658781
• Kai P. Law*, Xinxin Li, and Chuanlun L. Zhang. Lipidomics in archaeal membrane adaptation to environmental stresses and growth conditions: A review of culture-based physiological studies. SCIENCE CHINA Earth Sciences 63 (2020).
• Kai P. Law* and Chuanlun L. Zhang. Current progress and future trends of mass spectrometry-based archaeal lipidomics. Organic Geochemistry, 134 (2019) 45–61.
• Xun Mao, Xuyang Chen, Chang Chena, Hua Zhang, Kai P. Law*. Metabolomics in gestational diabetes. Clinica Chimica Acta, 475 (2017) 116–127.
• Ting-Li Han, Ying Yang, Hua Zhang, Kai P. Law*. Analytical Challenges of Untargeted GC-MS-based Metabolomics and the Critical Issues in Selecting the Data Processing Strategy. F1000Research 2017, 6:967.
• Kai P. Law* and Hua Zhang. The Pathogenesis and Pathophysiology of Gestational Diabetes Mellitus: Deductions from a Three-part Longitudinal Metabolomics Study in China. Clinica Chimica Acta, 468 (2017) 60–70.
• Kai P. Law*, Ting-Li Han, Xun Mao, and Hua Zhang. Tryptophan and Purine Metabolites are consistently upregulated in the Urinary Metabolome of Patients Diagnosed with Gestational Diabetes Mellitus throughout Pregnancy: A Longitudinal Metabolomics Study of Chinese Pregnant Women Part 2. Clinica Chimica Acta, 468 (2017) 126–139.
• Kai P. Law*, Xun Mao, Ting-Li Han, and Hua Zhang. Unsaturated Plasma Phospholipids are consistently lower in the Patients Diagnosed with Gestational Diabetes Mellitus throughout the Gestation: A Longitudinal Metabolomics Study of Chinese Pregnant Women Part 1. Clinica Chimica Acta. 465 (2017) 53–71.
• Yue Wang, Linqiang Ma, Xiaoyu Shu, Jiayu Li, Jinbo Hu, Kai P. Law, Ting Luo, Richa Goswami, Shumin Yang, Suhua Zhang, and Qifu Li. Apparent mineralocorticoid excess caused by a novel mutation in 11b-hydroxysteroid dehydrogenase type 2 gene. Journal of Hypertension, 35 (3), 647-650 (2017).
• Aihua Hou, Kai Pong Law, Min Qi Tin, and Louis Tong. In vitro Secretomics study of Pterygium-derived Fibroblasts by iTRAQ-based Quantitative Proteomics Strategy. Experimental Eye Research. 153, 14–22 (2016). Equally contributed author.
• Kai P. Law*, and Ting-Li Han. The Importance of Suitable GC-MS Data Processing and Analysis for Environmental Metabolomics. Environmental Science and Pollution Research 23 (10) 0276-10285, (2016).
• Kai P. Law*, Ting-Li Han, Philip N. Baker. Mass Spectrometry-based Proteomics for Pre-eclampsia and Preterm Birth. International Journal of Molecular Sciences 16 (5), 10952­10985 (2015).
• V. Iyengar, P. Jaynes, L. Rodon, D. Lama, Kai P. Law, C. Verma, J. Seoane & P. J. A. Eichhorn. USP15 regulates SMURF2 kinetics through C-lobe-mediated deubiquitination. Scientific Reports, 5, 14755 (2015).
• Hou, W. Lan, Kai P. Law, SCJ Khoo, M.Q. Tin, L. Tong. Evaluation of Global Differential Gene and Protein Expression in Primary Pterygium: S100A8 and S100A9 as Possible Drivers of a Signaling Network. PLoS ONE 9(5): e97402 (2014).

(Full list of publications can be found in Google Scholar)

Professional interests

My research interest lies in biological and clinical mass spectrometry and specialises in mass spectrometry-based omics approaches (metabolomics, lipidomics, proteomics and bioinformatics), using LC-MS and MALDI-MS. 

Qualifications

Ph.D. in Pharmacy University of Nottingham (2008)

Experience in industry

Shenzhen SMQ Medical Laboratory, Shenzhen Academy of Metrology & Quality Inspection

Nanomics Biotechnology, Inc.

International experience

I have worked in Hong Kong, Singapore, Mainland China, and Twain China.